Rice University

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Thesis Defense

Graduate and Postdoctoral Studies
Electrical and Computer Engineering

Speaker: Sterling Noelck
Masters Candidate

Evaluating the Effects of Cell Sample Preparation on FTIR Cancer Detection

Friday, April 12, 2013
12:15 PM  to 1:15 PM

A227  Anderson Biological Laboratories

This thesis examines some of the challenges involved with using FTIR spectroscopy for cancer detection including sample preparation and correcting for distortion from cell scattering. Sample preparation affects the spectra differently depending on the cell type, and can lead to significant changes in cancer biomarkers for a given cell type. Biomarkers derived from specific cancer types under one sample preparation are not be reliable for other cancer types, and may not be suitable for the same cancer type using a different sample preparation. Cell scattering can also significantly affect the cell spectra, and as a result, correcting for the cell scattering distortion leads to changes in the biomarkers. For reliable cancer detection controlling variability is critical, especially in the complex spectra of biological samples. Standard sample preparation methods and scattering correction post-processing could improve comparison of cancer detection

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