Rice University

Events at Rice


Materials Science & NanoEngineering

Speaker: Wah Chiu
Professor of Biochemistry & Molecular Biology
Baylor College of Medicine

MSNE Seminar Series - Prof. Wah Chiu "Opportunities and Challenges in cryoEM for Structural Research" (450/451/500)

Thursday, February 16, 2017
3:00 PM  to 4:00 PM

180  Dell Butcher Hall
Rice University
6100 Main St
Houston, Texas, USA

Electron cryo-microscopy (cryoEM) is in the midst of a rapid advance in resolving biological structures of molecular machines previously either difficult or impossible to attain, at near atomic resolutions. In our Center, we have solved cryoEM structures of molecular machines, including viruses, chaperonins, protein complexes and membrane proteins, to the level where full-atom models of the protein components can be obtained from cryoEM maps. Examples will be presented illustrating how novel biochemical knowledge is derived and validated from cryoEM structures.

Biography of Wah Chiu:
Wah Chiu has been an investigator in the development of experimental and computational methodologies for structural determination of biological assemblies by single particle cryo-electron microscopy (cryo-EM) towards atomic resolution for over three decades. He received his B.A. in Physics and also Ph.D. in Biophysics from University of California Berkeley. After staying at the Lawrence Berkeley Laboratory as a staff scientist for a few years, Dr. Chiu joined the University of Arizona to start his academic career and from there joined the Department of Biochemistry and Molecular Biology at Baylor College of Medicine in 1988. He is a member of the National Academy of Sciences, USA and also an elected academician of Acadmic Sinica, Taiwan. Professor Chiu’s National Center for Macromolecular Imaging has inspired many scientists around the world to use cryo-EM and has disseminated their facilities, methodologies and software freely to the academic community.

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