Center for Theoretical Biological Physics
Chemical and Biomolecular Engineering
Dean of Engineering
Dean of Natural Sciences
Physics & Astronomy
Department of Mathematics, University of British Columbia
'Signaling in Cell Shape and Motility: from Single Cells to the Collective Behavior of Multiple Cells”
Tuesday, February 14, 2017
to 1:30 PM
1060 A/B BioScience Research Collaborative
6500 Main St.
Houston, Texas, USA
Abstract: In this talk I will describe recent work on the signaling inside cells that controls the cytoskeleton, and thereby the shape and motility of a eukaryotic cell. I will focus on our recent analysis of regulatory proteins (the small GTPases Ran and Rho, known to be mutually antagonistic), and how their interactions can account for cell spreading, contraction, and polarization. An application to the experimentally observed dynamics of melanoma cells will be highlighted. I will also describe some of our recent work spanning the single and multiple cell levels. An example of the subdivision of a developing tissue (lateral line primordial) in the zebrafish embryo will be described.