Rice University

Events at Rice

Thesis Defense

Graduate and Postdoctoral Studies
Bioengineering

Speaker: Songi Han
Doctoral Candidate

Production of Short Chain Fatty Acid and its Derivatives by Genetically Engineered Escherichia coli

Tuesday, April 11, 2017
3:00 PM  to 5:00 PM

801  BioScience Research Collaborative


Fatty acids are considered as valuable compounds to have a potency to be diversified into other derivatives enzymatically or chemically. Due to increasing concern regarding soaring oil price and environmental crisis, alternative ways to reduce the dependency on petroleum have been received much attention, of which biocatalyst processing has been the subject of intensive research as bio-renewable approach. Our group has generated the platform to synthesis a wide range of fatty acids with tailored chain length and functional group by using E. coli as a host. Considerable efforts have been made, and the corresponding improvement in the production of fatty acid has been achieved so far. Since this progress is limited to long chain length fatty acid in most cases, we have made an attempt to customize the chain length shorter than C12 by exploiting some strategies used in metabolic engineering. As a result of adopting many metabolic engineering strategies, we have found a significant improvement in the production of short chain fatty acid.

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