Graduate and Postdoctoral Studies
A Tunable Snapshot Hyperspectral Imager for Retinal Oximetry
Wednesday, April 19, 2017
to 12:00 PM
285 BioScience Research Collaborative
In this work, a snapshot hyperspectral imager capable of tuning its average spectral resolution from 22.7 nm to 13.9 nm in a single integrated form is presented. The principle of this system will enable future snapshot systems to dynamically adapt to a wide range of imaging situations. Additionally, the system overcomes datacube size limitations imposed by detector array size limits. The work done in this thesis also advances oximetry of the retina using data collected by the Image Mapping spectrometer (IMS), a snapshot spectrometer. Hyperspectral images of the retina are acquired, and oximetry of individual vessels in 4 diseased eyes is presented. Further, oximetry of the fundus tissue is performed using a novel algorithm with data collected with the IMS. We present oxyhemoglobin concentration maps of the eye and demonstrate oxygen sensitivity of the maps by comparing normal and diseased eyes. The aim of this work is to advance the general capabilities of snapshot hyperspectral imagers and to improve the ability of ophthalmologists to monitor and diagnose retinal diseases.